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| 产品： |
浏览次数：706ZM447439 抑制剂 |
| 品牌： |
美国进口 |
| 产品型号： |
331771-20-1 |
| 产品规格： |
5mg,25mg |
| 最小起订量： |
5 mg |
| 供货总量： |
100 mg |
| 发货期限： |
自买家付款之日起 3 天内发货 |
| 有效期至： |
长期有效 |
| 最后更新： |
2022-12-26 10:54 |
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Description
ZM447439 inhibits aurora kinases A and B (AurA, AurB), preventing mitotic spindle formation and proper completion of mitosis. This compound exhibits anticancer activity, inducing hyperploidy and apoptosis in osteosarcoma cells and inhibiting growth in mesothelioma cells. ZM447439 also induces apoptosis and inhibits expression of AurB and H3-P protein in cervical cancer cells, suppressing growth and survival.
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| Specifications |
| Cas No. |
331771-20-1 |
| Product ID |
Z4900 |
| Product Name |
ZM447439 抑制剂 |
| Formula Wt. |
567.63 |
| Store Temp |
-20°C |
| References |
Tavanti E, Sero V, Vella S, et al. Preclinical validation of Aurora kinases-targeting drugs in osteosarcoma. Br J Cancer. 2013 Nov 12;109(10):2607-18. PMID: 24129234.
Baldini E, Tuccilli C, Prinzi N, et al. The dual Aurora kinase inhibitor ZM447439 prevents anaplastic thyroid cancer cell growth and tumorigenicity. J Biol Regul Homeost Agents. 2013 Jul-Sep;27(3):705-15. PMID: 24152827.
Crispi S, Fagliarone C, Biroccio A, et al. Antiproliferative effect of Aurora kinase targeting in mesothelioma. Lung Cancer. 2010 Dec;70(3):271-9. PMID: 20371132. |
Shanghai HuicH Biotech Co.，Ltd.
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