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Vortioxetine 原装进口分析标准品
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产品： 浏览次数：681Vortioxetine 原装进口分析标准品 
品牌： 进口
产品型号： 508233-74-7
产品规格： 5mg 10mg 25mg
最小起订量： 5 mg
供货总量： 1000 mg
发货期限： 自买家付款之日起 3 天内发货
有效期至： 长期有效
最后更新： 2023-03-02 13:54
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详细信息
 Vortioxetine


Description
Vortioxetine is an antidepressant and anxiolytic. Vortioxetine modulates serotonin levels in the brain by inhibiting the serotonin transporter and 5-HT3A,7 receptors, acting as a partial agonist at the 5-HT1B receptor, and acting as a full agonist at the 5-HT1A receptor. Vortioxetine also shows some agonist activity at β1-adrenergic receptors, although this is likely not related to its beneficial activities. In addition to its mood-modulating action, this compound also improves memory performance and reduces 5-HT-depletion-induced memory deficits in object recognition and Y-maze spontaneous alternation tests.
Specifications
Cas No. 508233-74-7
Product ID HV5870
Product Name Vortioxetine   原装进口分析标准品
Formula C18H22N2S
Formula Wt. 298.45
Purity >98%
Store Temp Ambient
References du Jardin KG, Jensen JB, Sanchez C, et al. Vortioxetine dose-dependently reverses 5-HT depletion-induced deficits in spatial working and object recognition memory: A potential role for 5-HT1A receptor agonism and 5-HT3 receptor antagonism. Eur Neuropsychopharmacol. 2013 Aug 2. [Epub ahead of print]. PMID: 23916504. 

Henigsberg N, Mahableshwarkar AR, Jacobsen P, et al. A randomized, double-blind, placebo-controlled 8-week trial of the efficacy and tolerability of multiple doses of Lu AA21004 in adults with major depressive disorder. J Clin Psychiatry. 2012 Jul;73(7):953-9. PMID: 22901346. 

Bang-Andersen B, Ruhland T, Jørgensen M, et al. Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder. J Med Chem. 2011 May 12;54(9):3206-21. PMID: 21486038.


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