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您当前的位置： 首页 » 供应产品 » 1,8-二羟基-3-羟甲基蒽醌/芦荟泻素//Aloe-emodin 1,8-二羟基-3-羟甲基蒽醌/芦荟泻素//Aloe-emodin
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| 产品： |
浏览次数：7641,8-二羟基-3-羟甲基蒽醌/芦荟泻素//Aloe-emodin |
| 品牌： |
进口 |
| 产品型号： |
481-72-1 |
| 产品规格： |
100mg 250mg |
| 最小起订量： |
100 mg |
| 供货总量： |
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| 发货期限： |
自买家付款之日起 3 天内发货 |
| 有效期至： |
长期有效 |
| 最后更新： |
2024-07-03 09:43 |
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Description
Aloe-emodin is an anthraquinone isolated from the aloe plant. Aloe-emodin is most commonly known for its stimulant-laxative action, but also shows antioxidative, anticancer, and antiangiogenic activity. This compound activates CFTR Cl- channels in the colon, potentially increasing fluid secretion and resulting in laxative activity. Aloe-emodin acts on a number of targets in cellular models of cancer, including p65lck, ERα, NF-κB, and mTORC2. Additionally, aloe-emodin induces apoptosis in vivo through disruption of the mitochondria membrane potential.
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| Specifications |
| Cas No. |
481-72-1 |
| Product ID |
HA4617 |
| Product Name |
Aloe-emodin |
| Chemical Name |
1,8-Dihydroxy-3-(hydroxymethyl)-9,10-anthracenedione |
| Formula Wt. |
270.24 |
| Melting Point |
223 - 224 ºC |
| Purity |
>98% |
| Store Temp |
-20°C |
| References |
Ismail S, Haris K, Abdul Ghani AR, et al. Enhanced induction of cell cycle arrest and apoptosis via the mitochondrial membrane potential disruption in human U87 malignant glioma cells by aloe emodin. J Asian Nat Prod Res. 2013 Jul 22. [Epub ahead of print]. PMID: 23869465.
Huang PH, Huang CY, Chen MC, et al. Emodin and Aloe-Emodin Suppress Breast Cancer Cell Proliferation through ER α Inhibition. Evid Based Complement Alternat Med. 2013; Epub 2013 Jun 24. PMID: 23864887.
Zhang W, Chen H, Liu DL, et al. Emodin sensitizes the gemcitabine-resistant cell line Bxpc-3/Gem to gemcitabine via downregulation of NF-κB and its regulated targets. Int J Oncol. 2013 Apr;42(4):1189-96. PMID: 23440366.
Liu K, Park C, Li S, et al. Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2. Carcinogenesis. 2012 Jul;33(7):1406-11. PMID: 22532249.
Yang H, Xu LN, He CY, et al. CFTR chloride channel as a molecular target of anthraquinone compounds in herbal laxatives. Acta Pharmacol Sin. 2011 Jun;32(6):834-9. PMID: 21602836.
Srinivas G, Babykutty S, Sathiadevan PP, et al. Molecular mechanism of emodin action: transition from laxative ingredient to an antitumor agent. Med Res Rev. 2007 Sep;27(5):591-608. PMID: 17019678. |
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