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沙蟾蜍精 Arenobufagin
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产品: 浏览次数:770沙蟾蜍精 Arenobufagin 
品牌: 进口
产品型号: 464-74-4
产品规格: 1mg 5mg 25mg
最小起订量: 1 mg
供货总量:
发货期限: 自买家付款之日起 3 天内发货
有效期至: 长期有效
最后更新: 2023-06-07 14:11
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详细信息
Arenobufagin
Description
Arenobufagin is a bufanolide steroid isolated from the Argentine toad Bufo arenarum. This compound exhibits anticancer and antiangiogenic properties, but is also cardiotoxic, inhibiting cardiovascular Na+/K+ pumps. In cellular models, arenobufagin modulated autophagy and apoptosis, inhibiting tumor growth through indirect inhibition of the PI3K/Akt/mTOR signaling pathway. Arenobufagin also inhibits VEGFR2 directly through blockade of ATP-binding sites.
Specifications
Cas No. 464-74-4
Product ID HA6818
Product Name Arenobufagin
Formula Wt. 416.51
Store Temp -20°C
References Zhang DM, Liu JS, Deng LJ, et al. Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway. Carcinogenesis. 2013 Jun;34(6):1331-42. PMID: 23393227. 

Li M, Wu S, Liu Z, et al. Arenobufagin, a bufadienolide compound from toad venom, inhibits VEGF-mediated angiogenesis through suppression of VEGFR-2 signaling pathway. Biochem Pharmacol. 2012 May 1;83(9):1251-60. PMID: 22305746. 

Cruz Jdos S, Matsuda H. Arenobufagin, a compound in toad venom, blocks Na(+)-K+ pump current in cardiac myocytes. Eur J Pharmacol. 1993 Aug 3;239(1-3):223-6. PMID: 8223897. 

Garraffo HM, Gros EG. Biosynthesis of bufadienolides in toads. VI. Experiments with [1,2-3H]cholesterol, [21-14C]coprostanol, and 5 beta-[21-14 C]pregnanolone in the toad Bufo arenarum. Steroids. 1986 Sep-Oct;48(3-4):251-7. PMID: 3127947.

 

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