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桔皮素分析标准品 Tangeretin
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产品： 浏览次数：333桔皮素分析标准品 Tangeretin 
品牌： 进口
产品型号： HT0253
产品规格： 5mg,10mg
最小起订量： 5 mg
供货总量： 100 mg
发货期限： 自买家付款之日起 3 天内发货
有效期至： 长期有效
最后更新： 2024-07-08 11:26
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详细信息
 
Description
Tangeretin is a polymethoxy flavonoid isolated from citrus fruits. This compound exhibits a wide variety of health-related benefits, including anti-inflammatory, anti-allergy, anti-diabetic, and anticancer activities. In an in vivo model of skin-base allergic reaction, administration of tangeretin inhibits expression of IL-4 and TNF-alpha as well as inhibiting activation of NF-kB, AP-1, and p38. In both in vitro and in vivo models of diabetes mellitus, tangeretin increased AMP-K phosphorylation and glucose uptake and altered secretion of adipocytokines such as leptin, adiponectin, resistin, IL-6, and MCP-1. Additionally, this compound induced cell cycle arrest and inhibited proliferation of several cancer cell lines. Tangeretin also inhibits osteoclast formation, suggesting potential benefit as a treatment for bone diseases.
Specifications
Cas No. 481-53-8
Product ID HT0253
Product Name Tangeretin    桔皮素分析标准品
Formula C20H20O7
Formula Wt. 372.37
Purity ≥98%
References Jang SE, Ryu KR, Park SH, et al. Nobiletin and tangeretin ameliorate scratching behavior in mice by inhibiting the action of histamine and the activation of NF-κB, AP-1 and p38. Int Immunopharmacol. 2013 Aug 9;17(3):502-507. PMID: 23938254. 

Tominari T, Hirata M, Matsumoto C, et al. Polymethoxy flavonoids, nobiletin and tangeretin, prevent lipopolysaccharide-induced inflammatory bone loss in an experimental model for periodontitis. J Pharmacol Sci. 2012;119(4):390-4. PMID: 22850615. 

Kim MS, Hur HJ, Kwon DY, et al. Tangeretin stimulates glucose uptake via regulation of AMPK signaling pathways in C2C12 myotubes and improves glucose tolerance in high-fat diet-induced obese mice. Mol Cell Endocrinol. 2012 Jul 6;358(1):127-34. PMID: 22476082. 

Morley KL, Ferguson PJ, Koropatnick J. Tangeretin and nobiletin induce G1 cell cycle arrest but not apoptosis in human breast and colon cancer cells. Cancer Lett. 2007 Jun 18;251(1):168-78. PMID: 17197076.

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