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Description
Sulpiride is an antipsychotic that functions as an antagonist at D2/3 receptors and also up-regulates and activates the GHB receptor. In vivo, sulpiride ameliorates increased impulsivity and attentional impairment in PFC-lesioned models of schizophrenia. Additionally, because dopamine inhibits prolactin release, sulpiride’s inhibition of dopamine results in increased concentrations of prolactin as well as melanocyte-stimulating hormone.
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| Specifications |
| Cas No. |
23672-07-3 |
| Product ID |
HS8345 |
| Product Name |
S-(-)-Sulpiride 分析标准品 |
| Formula Wt. |
341.43 |
| Melting Point |
178-180 ºC |
| Purity |
>99% |
| Store Temp |
Ambient |
| References |
Valencia NA, Thompson DL Jr, Mitcham PB. Changes in plasma melanocyte-stimulating hormone, ACTH, prolactin, GH, LH, FSH, and thyroid-stimulating hormone in response to injection of sulpiride, thyrotropin-releasing hormone, or vehicle in insulin-sensitive and -insensitive mares. Domest Anim Endocrinol. 2013 May;44(4):204-12. PMID: 23571008.
Pezze MA, Dalley JW, Robbins TW. Remediation of attentional dysfunction in rats with lesions of the medial prefrontal cortex by intra-accumbens administration of the dopamine D(2/3) receptor antagonist sulpiride. Psychopharmacology (Berl). 2009 Jan;202(1-3):307-13. PMID: 18985321.
Ratomponirina C, Gobaille S, Hodé Y, et al. Sulpiride, but not haloperidol, up-regulates gamma-hydroxybutyrate receptors in vivo and in cultured cells. Eur J Pharmacol. 1998 Apr 10;346(2-3):331-7. PMID: 9862377. |
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