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CAL101 标准品
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产品： 浏览次数：847CAL101 标准品 
品牌： 进口
产品型号： 870281-82-6
产品规格： 1mg 5mg 10mg
最小起订量： 1 mg
供货总量：
发货期限： 自买家付款之日起 3 天内发货
有效期至： 长期有效
最后更新： 2024-07-08 11:26
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详细信息
  CAL101
Description
CAL101 is an inhibitor of p110δ PI3K that is currently under examination as a potential treatment for leukemias such as mantle cell lymphoma and chronic lymphocytic leukemia (CLL). CAL101 exhibits anticancer chemotherapeutic and immunosuppressive activities. In mantle cell lymphoma cells, CAL101 induces G1 phase cell cycle arrest and apoptosis. In non-Hodgkin lymphoma and CLL cells, CAL101 inhibits downstream phosphorylation of Akt and induces apoptosis. Additionally, this compound inhibits cell chemotaxis, decreases chemokine production, inhibits migration, and prevents ERK- and Akt-dependent B-cell receptor signaling in CLL cells.
Specifications
Cas No. 870281-82-6
Product ID HC0044
Product Name CAL101
Synonym Idelalisib, GS1101
Formula Wt. 415.42
Store Temp +4°C
References Chiron D, Martin P, Di Liberto M, et al. Induction of prolonged early G1 arrest by CDK4/CDK6 inhibition reprograms lymphoma cells for durable PI3Kδ inhibition through PIK3IP1. Cell Cycle. 2013 Jun 15;12(12):1892-900. PMID: 23676220. 

Meadows SA, Vega F, Kashishian A, Johnson D, et al. PI3Kδ inhibitor, GS-1101 (CAL-101), attenuates pathway signaling, induces apoptosis, and overcomes signals from the microenvironment in cellular models of Hodgkin lymphoma. Blood. 2012 Feb 23;119(8):1897-900. PMID: 22210877. 

Hoellenriegel J, Meadows SA, Sivina M, et al. The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia. Blood. 2011 Sep 29;118(13):3603-12. PMID: 21803855.

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