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Description
12-Desmethyl Spirolide C is a cyclic imine marine toxin produced by species of the dinoflagellate Alexandrium. Spirolide C is a fast-acting shellfish poison that inhibits a variety of nicotinic acetylcholine receptors (nAChRs) such as α7, α4β2, and α3β4. Spirolide C inhibits nAChRs in skeletal muscle, producing neuromuscular block, and in neurons, decreasing action potential duration. This compound also inhibits muscarinic acetylcholine receptors (mAChRs). Additionally, spirolide C increases levels of N-acetyl aspartate and synaptophysin and decreases levels of amyloid-β (Aβ) in the hippocampus of transgenic Alzheimer’s disease mouse models. |
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13-Desmethyl Spirolide C 分析标准品