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| 产品： |
浏览次数：592Coptisine Hydrochloride 盐酸黄连碱 标准品 |
| 品牌： |
进口 |
| 产品型号： |
6020-18-4 |
| 产品规格： |
1mg 5mg |
| 最小起订量： |
1 mg |
| 供货总量： |
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| 发货期限： |
自买家付款之日起 3 天内发货 |
| 有效期至： |
长期有效 |
| 最后更新： |
2024-07-03 09:43 |
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Description
Coptisine is an isoquinoline alkaloid originally isolated from a variety of sources, including species of Fumeria and Papavera. Coptisine exhibits a wide variety of beneficial properties, including cardioprotective, anti-inflammatory, neuromodulatory, antibacterial, and chemotherapeutic activities. Coptisine attenuates mitochondrial respiratory dysfunction, inhibits expression of RhoA/ROCK, and decreases myocardial apoptosis. Coptisine also inhibits proliferation of vascular smooth muscle cells, potentially through upregulation of Gadd45a and Rgc32 genes. Coptisine induces cell cycle arrest in vascular smooth muscle cells as well, decreasing levels of cyclin D1 and potentially inhibiting tubulin polymerization. In heart tissue, this compound inhibits expression of IL-6, TNF-α, and IL-1β, displaying cardioprotective benefit in animal models of ischemia/reperfusion. Coptisine inhibits proliferation in cancer cell lines. This compound also inhibits monoamine oxidase A (MAO-A) and exhibits antibiotic activity against gram negative bacteria Escherischia coli.
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| Specifications |
| Cas No. |
6020-18-4 |
| Product ID |
HC5863 |
| Product Name |
Coptisine Hydrochloride 盐酸黄连碱 |
| Formula Wt. |
355.77 |
| References |
Guo J, Wang SB, Yuan TY, et al. Coptisine protects rat heart against myocardial ischemia/reperfusion injury by suppressing myocardial apoptosis and inflammation. Atherosclerosis. 2013 Dec;231(2):384-91. PMID: 24267256.
Gong LL, Fang LH, Wang SB, et al. Coptisine exert cardioprotective effect through anti-oxidative and inhibition of RhoA/Rho kinase pathway on isoproterenol-induced myocardial infarction in rats. Atherosclerosis. 2012 May;222(1):50-8. PMID: 22387061.
Suzuki H, Tanabe H, Mizukami H, et al. Differential gene expression in rat vascular smooth muscle cells following treatment with coptisine exerts a selective antiproliferative effect. J Nat Prod. 2011 Apr 25;74(4):634-8. PMID: 21401114.
Yan D, Jin C, Xiao XH, et al. Antimicrobial properties of berberines alkaloids in Coptis chinensis Franch by microcalorimetry. J Biochem Biophys Methods. 2008 Apr 24;70(6):845-9. PMID: 17804078.
Tanabe H, Suzuki H, Mizukami H, et al. Double blockade of cell cycle progression by coptisine in vascular smooth muscle cells. Biochem Pharmacol. 2005 Oct 15;70(8):1176-84. PMID: 16140275.
Lin CC, Ng LT, Hsu FF, et al. Cytotoxic effects of Coptis chinensis and Epimedium sagittatum extracts and their major constituents (berberine, coptisine and icariin) on hepatoma and leukaemia cell growth. Clin Exp Pharmacol Physiol. 2004 Jan-Feb;31(1-2):65-9. PMID: 14756686.
Ro JS, Lee SS, Lee KS, et al. Inhibition of type A monoamine oxidase by coptisine in mouse brain. Life Sci. 2001 Dec 28;70(6):639-45. PMID: 11833714. |
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