 公司动态产品分类 联系方式 |
|
您当前的位置： 首页 » 供应产品 » 氯化两面针碱标准品 Nitidine Chloride 氯化两面针碱标准品 Nitidine Chloride
 点击图片查看原图 |
|
| 产品： |
浏览次数：623氯化两面针碱标准品 Nitidine Chloride |
| 品牌： |
进口 |
| 产品型号： |
13063-04-2 |
| 产品规格： |
1mg 5mg |
| 最小起订量： |
1 mg |
| 供货总量： |
25 mg |
| 发货期限： |
自买家付款之日起 3 天内发货 |
| 有效期至： |
长期有效 |
| 最后更新： |
2023-07-04 10:19 |
| |
 |
|
Shanghai HuicH Biotech Co.，Ltd.
上海惠诚生物2010年至今专注于食品检测方面的标准品,优势品牌系列:
药物: TRC LGC USP LKT Focus
植提标准品: Extrasynthese PhytoLab Chromadex CaroteNature
糖类: Elicityl TDB Ludger Megazyme Glycarbo
脂类: Nu-Chek Larodan Avanti Matreya
其他: TCI ERM Wako Jackson Cayman laysan
手机微信：17715331663 QQ:2303607288
|
Description
Nitidine is a benzophenanthridine alkaloid that exhibits chemotherapeutic, anti-inflammatory, anti-parasitic, and antifungal properties. In cancer cells, nitidine decreases phosphorylation of Akt and downregulates expression of matrix metalloproteinases 2 and 9, inhibiting cellular migration and invasion. In vivo, nitidine inhibits activation of JAK/STAT3, downregulates expression of cyclin D1, cyclin-dependent kinase 4 (CDK4), and Bcl-2, and upregulates expression of p21 and Bax, resulting in decreases in tumor weight and volume. Additionally, nitidine inhibits topoisomerase I and binds to DNA sequences containing alternating G and C base pairs. In macrophages, this compound decreases production of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 and inhibits phosphorylation of MAPK and activation of NF-κB. Nitidine also displays inhibitory activity against species of Plasmodium that are resistant to chloroquine and other antimalarial compounds.
|
| Specifications |
| Cas No. |
13063-04-2 |
| Product ID |
HN3577 |
| Product Name |
氯化两面针碱标准品 Nitidine Chloride |
| Formula |
C21H18ClNO4 |
| Formula Wt. |
383.82 |
| Store Temp |
Ambient |
| References |
Fang Z, Tang Y, Jiao W, et al. Nitidine chloride inhibits renal cancer cell metastasis via suppressing AKT signaling pathway. Food Chem Toxicol. 2013 Oct;60:246-51. PMID: 23911800.
Liao J, Xu T, Zheng JX, et al. Nitidine chloride inhibits hepatocellular carcinoma cell growth in vivo through the suppression of the JAK1/STAT3 signaling pathway. Int J Mol Med. 2013 Jul;32(1):79-84. PMID: 23613111.
Wang Z, Jiang W, Zhang Z, et al. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kappaB pathway in RAW 264.7 cells. J Ethnopharmacol. 2012 Oct 31;144(1):145-50. PMID: 22971898.
Bai LP, Zhao ZZ, Cai Z, et al. DNA-binding affinities and sequence selectivity of quaternary benzophenanthridine alkaloids sanguinarine, chelerythrine, and nitidine. Bioorg Med Chem. 2006 Aug 15;14(16):5439-45. PMID: 16730995.
Nyangulu JM, Hargreaves SL, Sharples SL, et al. Antimalarial benzo[c]phenanthridines. Bioorg Med Chem Lett. 2005 Apr 15;15(8):2007-10. PMID: 15808457.
Li D, Zhao B, Sim SP, et al. 2,3-Dimethoxybenzo[i]phenanthridines: topoisomerase I-targeting anticancer agents. Bioorg Med Chem. 2003 Feb 20;11(4):521-8. PMID: 12538017.
Del Poeta M, Chen SF, Von Hoff D, et al. Comparison of in vitro activities of camptothecin and nitidine derivatives against fungal and cancer cells. Antimicrob Agents Chemother. 1999 Dec;43(12):2862-8. PMID: 10582872. |
|
|
