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Description
Xanthohumol (XN) is a prenylated flavonoid isolated from hops that exhibits anticancer, atheroprotective, neuroprotective, and estrogenic activities. XN alters NF-kB signaling, decreases expression of pro-inflammatory cytokines IL-1-beta and MCP-1, and activated AMP-activated protein kinase. In a rodent model of cerebral ischemia, XN attenuated focal cerebral ischemia and improved neurobehavioral deficits by inhibiting ischemia-related increases in TNF-alpha, HIF-1alpha, iNOS, and free radical formation. XN also inhibited differentiation of preadipocytes and increased apoptosis in mature adipocytes, potentially playing a role in lipid metabolism. This compound may also play a preventative role against bone diseases, as it inhibits osteoclastogenesis by modulating RANKL signaling.
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| Specifications |
| Cas No. |
6754-58-1 |
| Product ID |
HX0254 |
| Product Name |
Xanthohumol 黄腐醇标准品 Xanthohumol |
| Formula Wt. |
354.40 |
| Purity |
≥98% |
| References |
Suh KS, Rhee SY, Kim YS, et al. Xanthohumol modulates the expression of osteoclast-specific genes during osteoclastogenesis in RAW264.7 cells. Food Chem Toxicol. 2013 Aug 27. [Epub ahead of print] PMID: 23994090.
Doddapattar P, Radovi B, Patankar JV, et al. Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE-deficient mice. Mol Nutr Food Res. 2013 May 3. [Epub ahead of print] PMID: 23650230.
Viola K, Kopf S, Rarova L, et al. Xanthohumol attenuates tumour cell-mediated breaching of the lymphendothelial barrier and prevents intravasation and metastasis. Arch Toxicol. 2013 Jul;87(7):1301-12. PMID: 23503627.
Yen TL, Hsu CK, Lu WJ, et al. Neuroprotective effects of xanthohumol, a prenylated flavonoid from hops (Humulus lupulus), in ischemic stroke of rats. J Agric Food Chem. 2012 Feb 29;60(8):1937-44. PMID: 22300539.
Monteiro R, Calhau C, Silva AO, et al. Xanthohumol inhibits inflammatory factor production and angiogenesis in breast cancer xenografts. J Cell Biochem. 2008 Aug 1;104(5):1699-707. PMID: 18348194.
Yang JY, Della-Fera MA, Rayalam S, et al. Effect of xanthohumol and isoxanthohumol on 3T3-L1 cell apoptosis and adipogenesis. Apoptosis. 2007 Nov;12(11):1953-63. PMID: 17874298. |
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Shanghai HuicH Biotech Co.，Ltd.
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