上海惠诚生物科技有限公司

Description

JQ-1 is a triazolothienodiazepine compound that inhibits the bromodomain (BRD) family of proteins. Although it is a diazepine-like compound, JQ-1 exhibits no sedative or anxiolytic efficacy. JQ-1 was initially in development as a non-hormonal male contraceptive, inhibiting bromodomain testis-specific protein BRDT and chromatin remodeling during spermatogenesis, therefore preventing sperm production. This compound also activates latent HIV-1 in vitro and inhibits T cell proliferation through down-regulation of T cell activation signals CD3, CD28, and CXCR4; JQ-1 is currently used as an experimental tool for examining mechanisms of HIV-1 latency. Additionally, JQ-1 exhibits anticancer activity in vitro and in vivo; through its inhibition of BRD4, JQ-1 suppresses Myc expression, IL-7R expression, and reduces JAK/STAT phosphorylation, inducing cell cycle arrest and prolonging cancer in a variety of cell lines.