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Description
Doxorubicin is an anthracycline that exhibits anticancer chemotherapeutic and anti-parasitic, antimalarial activities. Doxorubicin is a DNA intercalator that inhibits topoisomerase II and is clinically used to treat various cancers; it is part of the CHOP and ABVD chemotherapy regimens. Doxorubicin also promotes histone H2AX eviction from chromatin, limiting DNA repair mechanisms. Additionally, this compound inhibits growth of Plasmodium.
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| Specifications |
| Cas No. |
25316-40-9 |
| Product ID |
D5794 |
| Product Name |
Doxorubicin HCl 盐酸阿霉素 |
| Chemical Name |
(8S-cis)10-[(3-Amino-2,3,6-trideoxy-a-L-lyxo- hexopyranosyl)oxy-7,8,9,10-tetrahydro-6,8,11- trihydroxy-8-(hydroacetyl)-1-methoxy-5,12- naphthacenedione |
| Synonym |
Adriacin; Adriblastina; Adriamycin; Caelyx |
| Formula |
C27H29NO11 HCl |
| Formula Wt. |
579.99 |
| Melting Point |
204oC-205oC(dec.) |
| Purity |
≥98 % |
| Solubility |
Soluble in water, methanol or aq alcohols. Soluble in DMSO to 10 mg/mL. Insoluble in acetone, or chloroform. |
| Store Temp |
+4oC |
| Ship Temp |
Ambient |
| References |
Pang B, Qiao X, Janssen L, et al. Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin. Nat Commun. 2013;4:1908. PMID: 23715267.
Tacar O, Sriamornsak P, Dass CR. Doxorubicin: an updat on anticancer molecular action, toxicity and novel drug delivery systems. J Pharm Pharmacol. 2013 Feb;65(2):157-70. PMID: 23278683.
Gamo FJ, Sanz LM, Vidal J, et al. Thousands of chemical starting points for antimalarial lead identification. Nature. 2010 May 20;465(7296):305-10. PMID: 20485427. |
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