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Description
SN-38 is a camptothecin derivative. Camptothecin is a quinolone alkaloid precursor of irinotecan; it is originally isolated from Camptotheca. Camptothecin exhibits anticancer chemotherapeutic activity, inhibiting topoisomerase I and inducing double-stranded DNA breaks. Camptothecin is extremely cytotoxic and only its derivatives are clinically used as chemotherapeutics.
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| Specifications |
| Cas No. |
86639-52-3
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| Product ID |
C0154
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| Product Name |
Camptothecin, 7-ethyl-10-hydroxy (SN-38) 7-乙基-10-羟基喜树碱
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| Chemical Name |
4,11-diethyl-4,9-dihydroxy-1H-Pyrano[3',4':6,7]- indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
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| Synonym |
7-乙基-10-羟基喜树碱 SN-38; 7-ethyl-10-hydroxy-CPT
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| Formula |
C22H20N2O5 分子式
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| Formula Wt. |
392.4 分子量
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| Melting Point |
228oC-235oC
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| Purity |
≥98%
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| Stability |
Protect from light. 避光保存
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| Store Temp |
-20oC 低温
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| References |
Rodríguez-Berna G, Mangas-Sanjuán V, Gonzalez-Alvarez M, et al. A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability. Eur J Med Chem. 2014 Jun 25;83C:366-373. PMID: 24980118.
Berniak K, Rybak P, Bernas T, et al. Relationship between DNA damage response, initiated by camptothecin or oxidative stress, and DNA replication, analyzed by quantitative 3D image analysis. Cytometry A. 2013 Jul 11. [Epub ahead of print]. PMID: 23846844.
Redinbo MR, Stewart L, Kuhn P, et al. Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA. Science. 1998 Mar 6;279(5356):1504-13. PMID: 9488644.
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