Cat. Number |
A0919
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Chemical Name |
L-乙酰基肉碱 Acetyl-L-carnitine
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CAS Number |
3040-38-8
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Mol. Formula |
C9H17NO4
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Mol. Weight |
203.24
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Qty 1 |
1g
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Qty 2 |
5g
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Application Notes |
≥98%
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References |
Description
Acetyl-L-carnitine is a natural derivative of carnitine that enables functions of CoA and plays a significant role in the maintenance of energy homeostasis. Acetyl-L-carnitine exhibits antidepressant, neuroprotective, analgesic, and antinociceptive activities. In vivo, acetyl-L-carnitine acetylates p65, inducing NF-κB-mediated upregulation of mGluR2 receptors. In neuron-like PC12 cells, acetyl-L-carnitine inhibits 3-NPA-produced cellular stress responses and neurotoxicity. Acetyl-L-carnitine normalizes brain levels of neurotrophic factors such as NGF, GDNF, and artemin in animal models of neuropathy. Additionally, acetyl-L-carnitine exhibits some degree of antinociceptive benefit through indirect modulation of M1 muscarinic acetylcholine receptors (mAChRs). In cellular models of Alzheimer
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