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由烟曲霉(Aspergillus fumigatus)的发酵培养液中分离得到的一种抗生素。
黄色针状结晶。熔点194～195℃。旋光度[α]D25-26.6°(c=1,乙醇)。几乎不溶于水、稀酸类、饱和烃，溶于乙醇等溶剂。
Description
Fumagillin is an antimicrobial compound produced by species of Aspergillus that exhibits anti-parasitic, antimalarial, anti-fibrotic, anti-angiogenic, and anticancer chemotherapeutic activities. Fumagillin is clinically used to treat microsporidiosis and displays efficacy against Plasmodium, Nosema, and Enterocytozoon. In vivo, fumagillin decreases pulmo
nary fibrosis, pulmo
nary hypertension, and ventricular remodeling. In cellular and animal models of colorectal cancer, fumagillin inhibits type 2 methio
nine aminopeptidase, preventing tube and vessel formation and well as cell proliferation, migration, and adhesion; it also decreases tumor mass.
| Specifications |
| Cas No. |
23110-15-8 |
| Product ID |
F8048 |
| Product Name |
Fumagillin 烟曲霉素 |
| Chemical Name |
[3R-[3a,4a(2R*,3R*),5 |
| Synonym |
Amebacilin; Fugillin; Fumadil B: Fumidil |
| Formula |
C26H34O7 |
| Formula Wt. |
458.54 |
| Melting Point |
194oC-195oC |
| Purity |
≥98% |
| Solubility |
Soluble in most organic solvents. Practically insoluble in water, dilute acids and saturated hydrocarbons. |
| Stability |
Sensitive to light. |
| Store Temp |
-20oC |
| References |
Kass DJ, Rattigan E, Kahloon R, et al. Early treatment with fumagillin, an inhibitor of methionine aminopeptidase-2, prevents Pulmonary Hypertension in monocrotaline-injured rats. PLoS One. 2012;7(4):e35388. PMID: 22509410.
Champion L, Durrbach A, Lang P, et al. Fumagillin for treatment of intestinal microsporidiosis in renal transplant recipients. Am J Transplant. 2010 Aug;10(8):1925-30. PMID: 20636462.
Arico-Muendel C, Centrella PA, Contonio BD, et al. Antiparasitic activities of novel, orally available fumagillin analogs. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5128-31. PMID: 19648008.
Hou L, Mori D, Takase Y, et al. Fumagillin inhibits colorectal cancer growth and metastasis in mice: in vivo and in vitro study of anti-angiogenesis. Pathol Int. 2009 Jul;59(7):448-61. PMID: 19563408.
Chen X, Xie S, Bhat S, et al. Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo. Chem Biol. 2009 Feb 27;16(2):193-202. PMID: 19246010. |
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