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Description
Linezolid is an oxazolidinone antibiotic that exhibits antibacterial activity against gram positive bacteria. Linezolid binds to the A site of 23S rRNA on the 50S ribosomal subunit, inhibiting protein synthesis. Linezolid also decreases NMDA receptor-mediated current, but is less active than most other comparable antibacterial compounds.
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| Specifications |
| Cas No. |
165800-03-3 |
| Product ID |
L3453 |
| Product Name |
Linezolid 分析标准品 |
| Formula |
分子式 ：C16H20FN3O4 |
| Formula Wt. |
分子量：337.35 |
| Purity |
纯度 >98% |
| Solubility |
Moderately soluble in water (3 mg/mL). Soluble in DMSO (>20 mg/mL). |
| References |
Long KS, Vester B. Resistance to linezolid caused by modifications at its binding site on the ribosome. Antimicrob Agents Chemother. 2012 Feb;56(2):603-12. PMID: 22143525.
Kombian SB, Phillips OA. In vitro electrophysiological investigations of the acute effects of linezolid and novel oxazolidinones on central nervous system neurons. Neuroscience. 2011 Apr 28;180:53-63. PMID: 21296129.
Ippolito JA, Kanyo ZF, Wang D, et al. Crystal structure of the oxazolidinone antibiotic linezolid bound to the 50S ribosomal subunit. J Med Chem. 2008 Jun 26;51(12):3353-6. PMID: 18494460. |
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