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Description
Flufenamic acid is a COX-inhibiting non-steroidal anti-inflammatory drug (NSAID) that exhibits neuromodulatory, anti-inflammatory, antipyretic, analgesic, and antiepileptic/anticonvulsant activities. Flufenamic inhibits voltage-gated Na+ channels, transient receptor potential canonical 3 (TRPC3) channels, and transient receptor potential melastatin-like 2 (TRPM2) channels and potentiates TREK1 (KCNK2) channel activity. In vitro, flufenamic acid decreases glutamatergic excitatory activity and neuronal excitability.
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| Specifications |
| Cas No. |
530-78-9 |
| Product ID |
F4483 |
| Product Name |
Flufenamic acid 氟芬那酸 分析标准品 |
| Chemical Name |
2-[[3-(Trifluoromethyl)phenyl]amino]benzoic acid |
| Synonym |
Achless; Ansatin; Arlef; Fullsafe; Parlef; Sastridex; Tecramine |
| Formula |
分子式 C14H10F3NO2 |
| Formula Wt. |
分子量 281.23 |
| Melting Point |
125oC |
| Purity |
≥97% 纯度 |
| Solubility |
Soluble in 4 parts of ethanol. Soluble in DMSO to 100 mM and in ethanol to 100 mM |
| Store Temp |
Ambient |
| References |
Xie YF, Zhou F. TRPC3 channel mediates excitation of striatal cholinergic interneurons. Neurol Sci. 2014 May 21. [Epub ahead of print]. PMID: 24844791.
Veale EL, Al-Moubarak E, Bajaria N, et al. Influence of the N terminus on the biophysical properties and pharmacology of TREK1 potassium channels. Mol Pharmacol. 2014 May;85(5):671-81. PMID: 24509840.
Nazrolu M, zgül C, elik , et al. Aminoethoxydiphenyl borate and flufenamic acid inhibit Ca2+ influx through TRPM2 channels in rat dorsal root ganglion neurons activated by ADP-ribose and rotenone. J Membr Biol. 2011 May;241(2):69-75. PMID: 21509529.
Yau HJ, Baranauskas G, Martina M. Flufenamic acid decreases neuronal excitability through modulation of voltage-gated sodium channel gating. J Physiol. 2010 Oct 15;588(Pt 20):3869-82. PMID: 20724367.
Fernández M, Lao-Peregrín C, Martín ED. Flufenamic acid suppresses epileptiform activity in hippocampus by reducing excitatory synaptic transmission and neuronal excitability. Epilepsia. 2010 Mar;51(3):384-90. PMID: 19732136. |
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