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Description
Cerulenin is an inhibitor of fatty acid synthase isolated from Cephalosporium. Cerulenin exhibits antibiotic, antifungal, and anticancer chemotherapeutic activities. In cellular and animal models of colon cancer, cerulenin induces apoptosis and cellular death and decreases tumor growth. Cerulenin may also inhibit insulin secretion.
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| Specifications |
| Cas No. |
17397-89-6 |
| Product ID |
C1869 |
| Product Name产品名称 |
Cerulenin 浅蓝菌素 分析标准品 |
| Chemical Name化学名称 |
(2R,3S)-3-[(4E,7E)-1-Oxo-4,7-nonadienyl]oxirane- carboxamide |
| Synonym其他名称 |
Helicocerin |
| Formula分子式 |
C12H17NO3 |
| Formula Wt.分子量 |
223.27 |
| Melting Point 熔点 |
93oC-94oC |
| Purity纯度 |
≥98% |
| Solubility溶解性 |
Soluble in ethanol, acetone, or benzene. Slightly soluble in water. |
| Store Temp储存温度 |
-20oC |
| References相关文献 |
Straub SG, Sharp GW. Inhibition of insulin secretion by cerulenin might be due to impaired glucose metabolism. Diabetes metab Res Rev. 2007 Feb;23(2):146-51. PMID: 16705622.
Price AC, Choi KH, Heath RJ, et al. Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism. J Biol Chem. 2001 Mar 2;276(9):6551-9. PMID: 11050088.
Huang P, Zhu S, Lu S, et al. Cerulenin inhibits growth of human colonic carcinoma in nude mice. Zhonghua Bing Li Xue Za Zhi. 2000 Dec;29(6):435-8. PMID: 11866947. |
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