上海惠诚生物科技有限公司

重组人白介素IL3(GMP级)

IL-3 (interleukin 3)  IL3 Protein, Human, Recombinant，又称IL-3，是一种强有力的促生长因子，属于IL-3家族。IL3/IL-3也属于白细胞介素组。

惠诚生物提供IL3 以及各类细胞因子，同时推出CHO稳定细胞株开发技术服务方案，详情咨询电话17715331663

IL3 Background Information

IL3 (interleukin 3), also known as IL-3, is a potent growth promoting cytokine which belongs to the IL-3 family. IL3/IL-3 also belongs to the group of interleukins. Interleukins are produced by a wide variety of body cells. The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4+ T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T, B, and hematopoietic cells. IL3/IL-3 is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. IL3/IL-3 has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders.

产品说明： 

Noggin属于一组可扩散蛋白，通过与TGF-β家族的配体结合来调节其活性。TGF-β配体与其天然拮抗剂之间的相互作用在发育过程中具有重要的生物学意义，在发育过程中，细胞反应会因信号分子的局部浓度而发生变化。初Noggin被鉴定为BMP-4拮抗剂，其作用对头部和其他背部结构的正确形成至关重要。因此，Noggin已被证明能够调节包括BMP-2、-7、-13和-14在内的其他BMP的活性。在小鼠体内靶向缺失noggin导致产前死亡，隐性表型表现为严重畸形的骨骼系统。相反，在成熟成骨细胞中过度表达noggin的转基因小鼠显示成骨细胞分化受损、骨形成减少和严重骨质疏松。

本产品由真核细胞表达的重组蛋白，是将蛋白基因接入稳定表达载体，转化CHO-K1细胞，经克隆筛选，质量验证，挑选的稳定表达株，由化学成分确定的培养基（不含有任何动物源成分）发酵制备，工艺稳定，保证了产品质量及批次间的一致性。

本产品为无菌冻干粉剂，由含有20mMPBS pH为7.2的蛋白溶液经0.2μm过滤后分装冻干。

规格参数：

货号：GMP-025       规格：50μg/1.0mg.

质量控制：

生物学活性：大于5.0 x 105IU/mg.

纯度：经高效液相色谱（SEC-HPLC）和SDS-PAGE检测，纯度大于95.0%.

内毒素：小于5EU/mg.

使用说明：

建议将冻干rhNoggin溶解在注射用水或灭菌的超纯水中，浓度不低于100μg/ml，以待进一步稀释至工作浓度。尽可能避免反复冻融。

复溶后的细胞因子：4℃可稳定储存7-10天；长期保存请分装后存放于-20℃。